Key result
Endothelin infusion increased plasma ANP concentration, mediating an increase in hematocrit via vascular permeability, while ANP antiserum led to an exaggerated increase in blood pressure (p<0.002).
Why the study?
Does endothelin infusion affect blood pressure and hematocrit through the release of atrial natriuretic peptide in nephrectomized rats?
Population
Anesthetized, bilaterally nephrectomized Sprague-Dawley rats
Comparison
Infusion of endothelin for 45 minutes, with or… vs Vehicle infusion
Design
Preclinical
Follow-up
45 minutes
Authors
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May inform endothelin-ANP volume mechanisms in rats; leaves open human hypertension relevance.
Does endothelin infusion affect blood pressure and hematocrit through the release of atrial natriuretic peptide in nephrectomized rats?
Endothelin-induced increases in hematocrit are mediated by the release of ANP, which increases vascular permeability to whole plasma, while ANP also blunts the hypertensive effect of endothelin.
Valentin et al. (1991) studied Anesthetized, bilaterally nephrectomized Sprague-Dawley rats. Endothelin infusion with or without rabbit anti-rat ANP antiserum vs. Vehicle infusion was evaluated on Blood pressure, hematocrit, and plasma immunoreactive ANP concentration. Endothelin infusion increased plasma ANP concentration, mediating an increase in hematocrit via vascular permeability, while ANP antiserum led to an exaggerated increase in blood pressure (p<0.002).
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