Key result
Hospitalized COVID-19 links to elevated cardiac troponin-T and higher LDL-C/HDL-C ratios versus healthy controls.
Why the study?
People with COVID-19 are at increased risk of cardiovascular and metabolic disorders, but the relationship between cardiac troponin-T and the LDL-C to HDL-C ratio with COVID-19 required investigation.
Are cardiac troponin-T and LDL-C to HDL-C ratio levels altered in hospitalized COVID-19 patients compared to healthy controls?
Case-Control (n=90)
Are cardiac troponin-T and LDL-C to HDL-C ratio levels altered in hospitalized COVID-19 patients compared to healthy controls?
p-value: p=0.025 and 0.000
Hospitalized COVID-19 patients exhibit significantly altered LDL-C:HDL-C ratios and cTnT levels, suggesting these inexpensive biomarkers may aid in assessing disease severity.
May indicate cardiac involvement in hospitalized COVID-19; hypothesis-generating for severity biomarkers pending prospective validation.
<ns4:p><ns4:bold>Background: </ns4:bold>People with coronavirus disease 2019 (COVID-19) are frequently at higher risk of developing cardiovascular and metabolic disorders, which are strongly related to the development of long-term illness and higher mortality. These effects may be caused by several interrelated processes, including the IL-6 driven cytokine storm or uncontrolled angiotensin II stimulation. In addition, the direct viral infection of cardiac myocytes is thought to cause cardiac injury because it increases metabolic demand, activates the immune system, and causes vasculature disruption. The objective of this study was to determine whether there is a relationship between cardiac troponin-T (cTnT) and low-density lipoprotein cholesterol (LDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio values with COVID-19.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> During the data collection stage, 90 participants were included, 45 healthy controls and 45 hospitalized patients diagnosed with COVID-19 using reverse transcription-quantitative PCR (RT-qPCR). Each participant provided 5 ml venous blood to begin analyzing cTnT and LDL-C:HDL-C ratio levels in their blood to see whether there is an association between the level of any of these markers and COVID-19 infection using SPSS version 23.</ns4:p><ns4:p> <ns4:bold>Results:</ns4:bold> This research reported a significant rise in the measured values of cTnT and LDL-C:HDL-C ratio in patients' blood compared to controls, with P-values of 0.025 and 0.000, respectively, in which alpha values < 0.05, These biomarkers hold the promise in predicting COVID-19 severity, and early treatment may help reduce complications.</ns4:p><ns4:p> <ns4:bold>Conclusions:</ns4:bold> Due to the fact that cTn is a diagnostic marker of disease activity and a strong independent predictor of negative events, its usage in emergency rooms may well be advantageous. If cTn is elevated, hospitalization may be indicated. A difference in the blood LDL-C:HDL-C ratio of COVID-19 patients demonstrated an association with the illness. Because lipid studies are inexpensive and reliable to do, they may aid clinicians in identifying the severity of COVID-19.</ns4:p>
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Khalid et al. (2022) conducted a case-control in COVID-19 (n=90). COVID-19 infection vs. Healthy controls was evaluated on Levels of cardiac troponin-T (cTnT) and LDL-C to HDL-C ratio (p=0.025 and 0.000). Hospitalized COVID-19 patients had significantly higher levels of cardiac troponin-T (P=0.025) and LDL-C to HDL-C ratio (P=0.000) compared to healthy controls.
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