Key result
Low LDL-C (<1.4 mmol/L) in hospitalized COVID-19 patients was associated with significantly higher mortality compared to LDL-C ≥1.4 mmol/L (13.04% vs 6.32%, p=0.047).
Why the study?
The lipid profile in hospitalized patients with COVID-19 depending on the outcome of its acute phase was not well characterized.
Does low LDL-C level predict mortality in hospitalized patients with COVID-19?
Population
623 hospitalized patients with COVID-19 over 18 years of age with lipid levels analyzed
Comparison
Lipid profiles compared according to acute phase outcomes
Design
International registry-based study
Authors
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Low LDL-C may flag higher mortality risk in hospitalized COVID-19; leaves open causality and need for prospective validation.
Cohort (n=623)
Yes
Does low LDL-C level predict mortality in hospitalized patients with COVID-19?
Absolute Event Rate: 13.04% vs 6.32%
p-value: p=0.047
A decrease in LDL-C levels during the acute phase of COVID-19 is significantly associated with increased mortality in hospitalized patients.
Arutyunov et al. (2022) conducted a cohort in COVID-19 (n=623). Low LDL-C (<1.4 mmol/l) vs. LDL-C ≥1.4 mmol/l was evaluated on Mortality (p=0.047). Low LDL-C (<1.4 mmol/L) in hospitalized COVID-19 patients was associated with significantly higher mortality compared to LDL-C ≥1.4 mmol/L (13.04% vs 6.32%, p=0.047).
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