Key result
Higher total cholesterol linked to ~55% lower mortality per /dL in hospitalized COVID-19 patients.
Why the study?
Early markers of poor prognosis in COVID-19 patients are needed, and the association of SARS-CoV-2 infection with lipid abnormalities and their prognostic role was evaluated.
Are lipid profile abnormalities associated with ICU admission and mortality in patients with COVID-19?
Observational (n=1,489)
No
Are lipid profile abnormalities associated with ICU admission and mortality in patients with COVID-19?
Lower levels of total cholesterol, HDL-c, and LDL-c are associated with increased risk of ICU admission and mortality in patients with COVID-19.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for cholesterol as COVID-19 mortality marker; leaves open causality versus confounding by illness severity.
INTRODUCTION: A small percentage of patients will develop a severe form of COVID-19 caused by SARS-CoV-2 infection. Thus, it is important to predict the potential outcomes identifying early markers of poor prognosis. In this context, we evaluated the association of SARS-CoV-2 infection with lipid abnormalities and their role in prognosis. METHODS: Single-center, retrospective, observational study of COVID-19 patients admitted from March to October 2020. Clinical and laboratory data, comorbidities, and treatments for COVID-19 were evaluated. Main outcomes including intensive care unit (ICU) admission and mortality were analyzed with a multivariable Cox proportional hazards regression model. RESULTS: We selected 1489 from a total of 2038 consecutive patients with confirmed COVID-19, who had a complete lipid profile before ICU admission. During the follow-up performed in 1109 patients, we observed a decrease in T-c, HDL-c, and LDL-c in 28.6%, 42.9%, and 30.4% of patients, respectively, and an increase in TG in 76.8%. The decrease of both T-c and HDL- c was correlated with a decrease in albumin levels (r = 0.39 and r = 0.37, respectively). Kaplan-Meier survival curves found an increased ICU admission in patients with lower T-c (HR 0.55, CI 0.36-0.86), HDL-c (HR 0.61, CI 0.45-0.84), and LDL-c (HR 0.85, CI 0.74-0.97). Higher values of T-c (HR 0.45, CI 0.36-0.57), HDL-c (HR 0.66, CI 0.54-0.81), and LDL-c (HR 0.86, CI 0.78-0.94) showed a protective effect on mortality. CONCLUSIONS: Abnormalities in lipid profile are a frequent complication of SARS-CoV-2 infection and might be related to morbidity and mortality.
No takes yet. Share an insight, caveat, or question.
Sampedro‐Núñez et al. (2021) conducted an observational in COVID-19 (n=1,489). Total cholesterol levels vs. Lower total cholesterol levels was evaluated on Mortality (HR 0.45, 95% CI 0.36-0.57). Higher values of total cholesterol showed a protective effect on mortality in hospitalized COVID-19 patients.
Synapse has enriched 10 related papers. Consider them for comparative context: