What is the clinical evidence from this study?

Study design: Observational. Population: COVID-19 (n=1489). Intervention: Total cholesterol levels vs. Lower total cholesterol levels. Primary outcome: Mortality (HR 0.45, 95% CI 0.36-0.57).

What does this research mean for the field?

Higher values of total cholesterol show a protective effect on mortality in hospitalized COVID-19 patients. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 19, 2021EndocrineOpen Access

Higher total cholesterol linked to ~55% lower mortality per 50 mg/dL in hospitalized COVID-19 patients.

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Why the study?

Early markers of poor prognosis in COVID-19 patients are needed, and the association of SARS-CoV-2 infection with lipid abnormalities and their prognostic role was evaluated.

Are lipid profile abnormalities associated with ICU admission and mortality in patients with COVID-19?

Population

1489 COVID-19 patients with complete lipid profile before ICU admission

Comparison

Patients with lower versus higher lipid profile values

Design

Single-center retrospective observational study

Key result

Higher values of total cholesterol showed a protective effect on mortality in hospitalized COVID-19 patients (HR 0.45 per 50 mg/dL variation).

Authors

MSMiguel Sampedro‐Núñez NAN. Aguirre-Moreno LFLucio Garcia-Fraile Fraile

Discussion

Member takes

Overview

Hypothesis-generating for cholesterol as COVID-19 mortality marker; leaves open causality versus confounding by illness severity.

Study Design

Type

Observational (n=1,489)

Multicenter

Structured PICO

Are lipid profile abnormalities associated with ICU admission and mortality in patients with COVID-19?

Population

1,489 hospitalized patients with confirmed COVID-19 and a complete lipid profile before ICU admission, followed during their hospital stay.

Outcome

Intensive care unit (ICU) admission and mortalityhard clinical

Main Result

Hazard Ratio: 0.45 (95% CI 0.36–0.57)

Lower levels of total cholesterol, HDL-c, and LDL-c are associated with increased risk of ICU admission and mortality in patients with COVID-19.

Limitations

Retrospective single-center study design limits generalization to other hospital settings.
Only included hospitalized patients, so findings may not extrapolate to non-hospitalized patients with milder disease.
Patients sought medical attention at varying stages in their illness course.
Some severe patients died before drawing a blood sample for lipid parameters and could not be included.

Cite This Study

Sampedro‐Núñez et al. (2021) conducted an observational in COVID-19 (n=1,489). Total cholesterol levels vs. Lower total cholesterol levels was evaluated on Mortality (HR 0.45, 95% CI 0.36-0.57). Higher values of total cholesterol showed a protective effect on mortality in hospitalized COVID-19 patients (HR 0.45 per 50 mg/dL variation).

synapsesocial.com/papers/6aab3aba261a27bafaf58aef https://doi.org/10.1007/s12020-021-02881-0

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October 19, 2021EndocrineOpen Access

Higher total cholesterol linked to ~55% lower mortality per 50 mg/dL in hospitalized COVID-19 patients.

View Full Paper

Ask AI

Bookmark

Why the study?

Early markers of poor prognosis in COVID-19 patients are needed, and the association of SARS-CoV-2 infection with lipid abnormalities and their prognostic role was evaluated.

Are lipid profile abnormalities associated with ICU admission and mortality in patients with COVID-19?

Population

1489 COVID-19 patients with complete lipid profile before ICU admission

Comparison

Patients with lower versus higher lipid profile values

Design

Single-center retrospective observational study

Key result

Higher values of total cholesterol showed a protective effect on mortality in hospitalized COVID-19 patients (HR 0.45 per 50 mg/dL variation).

Authors

MSMiguel Sampedro‐Núñez NAN. Aguirre-Moreno LFLucio Garcia-Fraile Fraile

Discussion

Member takes

Overview

Hypothesis-generating for cholesterol as COVID-19 mortality marker; leaves open causality versus confounding by illness severity.

Study Design

Type

Observational (n=1,489)

Multicenter

Structured PICO

Are lipid profile abnormalities associated with ICU admission and mortality in patients with COVID-19?

Population

1,489 hospitalized patients with confirmed COVID-19 and a complete lipid profile before ICU admission, followed during their hospital stay.

Outcome

Intensive care unit (ICU) admission and mortalityhard clinical

Main Result

Hazard Ratio: 0.45 (95% CI 0.36–0.57)

Lower levels of total cholesterol, HDL-c, and LDL-c are associated with increased risk of ICU admission and mortality in patients with COVID-19.

Limitations

Retrospective single-center study design limits generalization to other hospital settings.
Only included hospitalized patients, so findings may not extrapolate to non-hospitalized patients with milder disease.
Patients sought medical attention at varying stages in their illness course.
Some severe patients died before drawing a blood sample for lipid parameters and could not be included.

Cite This Study

synapsesocial.com/papers/6aab3aba261a27bafaf58aef https://doi.org/10.1007/s12020-021-02881-0

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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