Key result
COVID-19 was associated with lower levels of LDL-C, HDL, TG, and TC compared to controls, with levels decreasing progressively with disease severity.
Why the study?
The development and correlation of dyslipidemia in COVID-19 was unknown.
Does COVID-19 infection alter lipid profile parameters compared to matched controls?
Observational
No
Does COVID-19 infection alter lipid profile parameters compared to matched controls?
Severe COVID-19 is associated with progressive hypolipidemia, which inversely correlates with acute-phase reactants.
Answers are grounded in this paper and cite their sources.
Hypolipidemia may mark COVID-19 severity but should not alter lipid management; leaves open prognostic value and mechanisms.
Background and objective: The development and correlation of dyslipidemia is unknown in COVID-19. This investigation was performed to assess the pathological alterations in lipid profile and their association in COVID-19. Methods: This was a retrospective study performed on real-world patients to assess serum levels of LDL-C, HDL, TG, TC on COVID-19 patients (mild: 319; moderate: 391; critical: 357). Age- and gender-matched controls who had their lipid profiles in the same period were included as the control group. Results: LDL-C, HDL, TG, and TC levels were significantly lower in COVID-19 patients when compared with the control group (P < 0.001, 0.047, 0.045, <0.001, respectively). All parameters decreased gradually with COVID-19 disease severity (LDL-C: median (IQR), mild: 98 (91,134); moderate: 97 (81,113); critical: 68 (68,83); HDL: mild: 45 (37,50); moderate: 46 (41,50); critical: 40 (37,46); TG: mild: 186 (150,245); moderate: 156 (109,198); critical: 111 (98,154); TC: mild: 224 (212,238); moderate: 212 (203,213); critical: 154 (125,187)). Logistic regression demonstrated lipid profile as predictor of severity of COVID-19 disease. Conclusion: Hypolipidemia develops in increasing frequency with severe COVID-19 disease. It inversely correlates with levels of acute-phase reactants, indicating SARS-COV-2 as the causative agent for alteration in lipid and thyroid levels.
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Almas et al. (2022) conducted an observational in COVID-19. COVID-19 vs. Age- and gender-matched controls was evaluated on Serum levels of LDL-C, HDL, TG, and TC (p=<0.001). COVID-19 was associated with lower levels of LDL-C, HDL, TG, and TC compared to controls, with levels decreasing progressively with disease severity.
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