Why the study?
The development and correlation of dyslipidemia in COVID-19 was unknown.
Does COVID-19 infection alter lipid profile parameters compared to matched controls?
Population
COVID-19 patients (mild: 319; moderate: 391; critical: 357) and age- and gender-matched controls
Comparison
COVID-19 patients across severity levels vs age- and gender-matched controls
Design
Single-center retrospective study
Key result
COVID-19 was associated with significantly lower levels of LDL-C, HDL, TG, and TC compared to controls (P<0.001 for LDL-C and TC), with levels decreasing progressively with disease severity.
Authors
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Hypolipidemia may mark COVID-19 severity but should not alter lipid management; leaves open prognostic value and mechanisms.
Observational
No
Does COVID-19 infection alter lipid profile parameters compared to matched controls?
p-value: p=<0.001
Severe COVID-19 is associated with progressive hypolipidemia, which inversely correlates with acute-phase reactants.
Almas et al. (2022) conducted an observational in COVID-19. COVID-19 vs. Age- and gender-matched controls was evaluated on Serum levels of LDL-C, HDL, TG, and TC (p=<0.001). COVID-19 was associated with significantly lower levels of LDL-C, HDL, TG, and TC compared to controls (P<0.001 for LDL-C and TC), with levels decreasing progressively with disease severity.
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