Key result
Oral thymol pretreatment protects rats against adrenaline-induced myocardial injury by improving cardiac biomarkers.
Why the study?
Cardiovascular disease represents a vital global disease burden, motivating the assessment of the possible cardioprotective effect of thymol against adrenaline-induced myocardial injury in rats.
Does thymol prevent adrenaline-induced myocardial injury in rats?
Does thymol prevent adrenaline-induced myocardial injury in rats?
Thymol demonstrates cardioprotective effects against adrenaline-induced myocardial injury in a rat model via anti-oxidant, anti-inflammatory, and anti-apoptotic pathways.
Thymol's effects in this rat model are hypothesis-generating; should not change practice and require clinical validation.
Cardiovascular disease represents a vital global disease burden. This study aims to assess the possible cardioprotective effect of thymol against adrenaline-induced myocardial injury (MI) in rats. Furthermore the effect of thymol on cardiac function biomarkers, electrocardiogram (ECG) alterations, oxidative stress, inflammation, apoptosis and histopathological changes was assessed. MI was induced by adrenaline (2 mg/kg, s.c.) injected as a single dose for 2 consecutive days (24 h apart). Normal and control groups received the vehicle for 21 consecutive days. The other 3 groups were orally administered thymol (15, 30, 60 mg/kg) for 21 consecutive days and on day 22, adrenaline was injected as a single dose for 2 consecutive days. Then ECG examination, biochemical, histopathological, immunohistochemical analyses were carried out. Thymol reversed adrenaline-induced reduction of heart rate, prolongation of RR interval and elevation of ST interval. Thymol pretreatment significantly reduced serum aspartate dehydrogenase (AST), lactate dehydrogenase (LDH), and creatine kinase (CK) levels in MI rats. Oral pretreatment with thymol increased reduced glutathione (GSH), reduced malondialdehyde (MDA), nuclear factor-kappa B (NF-κB), and interleukin-1β (IL-1β) cardiac contents in MI rats. Additionally, thymol administration significantly decreased protein expression of caspase-3, increased Bcl-2 protein expression in cardiac tissue and ameliorated histopathological changes. This study reveals that thymol exerted cardioprotective effect against adrenaline-induced MI in rats evidenced by improving cardiac function, attenuating ECG and histopathological changes which may be partly mediated through its anti-oxidant, anti-inflammatory and anti-apoptotic effect.
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El‐Marasy et al. (2020) studied Adrenaline-induced myocardial injury. Thymol vs. Vehicle was evaluated on Cardiac function biomarkers, ECG alterations, oxidative stress, inflammation, apoptosis and histopathological changes. Oral pretreatment with thymol (15, 30, or 60 mg/kg) protected against adrenaline-induced myocardial injury in rats by improving cardiac biomarkers, ECG parameters, and histopathology.
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