Key result
Sex hormone influence on RAS expression highlights sex dimorphism as a novel diabetic kidney disease target.
Understanding sex dimorphism in RAS regulation may provide new therapeutic approaches for diabetic kidney disease.
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Sex hormone effects on RAS may offer new diabetic kidney disease targets; leaves open whether this improves outcomes in trials.
Clotet et al. (2016) conducted a review in Diabetic nephropathy. Sex hormones and RAS was evaluated. A review of the influence of sex hormones on renin-angiotensin system expression suggests that understanding sex dimorphism might provide a new approach for treating diabetic kidney disease.
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