Why the study?
Does genetic background influence the development of hypertension and renal injury following DOCA salt treatment in mice?
Population
Male mice of four strains: 129/Sv, C57BL/6, and F1 and F2 intercrosses of 129/Sv x C57BL/6, uninephrectomized.
Comparison
Deoxycorticosterone acetate salt treatment for 6… vs Controls receiving 1% NaCl for drinking
Design
Preclinical
Follow-up
6 weeks
Authors
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Genetic background markedly modulates DOCA-salt hypertension and renal injury severity in mice; supports strain selection as a key variable in preclinical models.
Does genetic background influence the development of hypertension and renal injury following DOCA salt treatment in mice?
The 129/Sv mouse strain is more susceptible to DOCA-induced hypertension and nephrosclerosis than the C57BL/6 strain, highlighting the importance of genetic background in experimental kidney disease models.
Andrea Hartner (2003) studied this question.
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