Key result
Combined administration of atropine and propranolol during heavy exercise reduced maximal oxygen uptake by 6%, whereas individual drugs did not alter it despite wide variations in heart rate.
Why the study?
Do atropine and propranolol affect the oxygen transport system during exercise in healthy subjects?
Do atropine and propranolol affect the oxygen transport system during exercise in healthy subjects?
A remarkably efficient arterial oxygen transport can be maintained during heavy exercise despite a wide variation in heart rate induced by autonomic blockade.
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Combined autonomic blockade may modestly limit VO2 max during heavy exercise; leaves open the compensatory role of heart rate in oxygen transport.
Ekblom et al. (1972) studied Healthy subjects. Atropine, propranolol, or both vs. Control conditions was evaluated on Maximal oxygen uptake. Combined administration of atropine and propranolol during heavy exercise reduced maximal oxygen uptake by 6%, whereas individual drugs did not alter it despite wide variations in heart rate.
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