Key result
Applied pressure modulates rat aortic hydraulic resistance, with medial resistance dominating above ~93 mmHg.
Population
Rat abdominal aorta (ex vivo experimental and computational model)
Design
Preclinical
Authors
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Hypothesis-generating for aortic wall hydraulics in rats; leaves open human translation and clinical relevance.
In a rat model, medial hydraulic resistance of the arterial wall dominates over intimal resistance at pressures above 93 mmHg due to pressure-induced compaction of the extracellular matrix.
Chooi et al. (2016) studied Hydraulic resistance of the arterial wall. Transmural pressure was evaluated on Hydraulic permeability and relative contributions of intima and media to hydraulic resistance. Applied pressure modulated the relative contributions of the intima and media to the hydraulic resistance of the rat abdominal aorta, with medial resistance dominating at pressures above ~93 mmHg.
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