Key result
Increasing driving pressure from 15% to 190% of normotensive values in a theoretical model of rat microvascular networks resulted in a 3.3-fold increase in flow resistance.
Effect estimate: 3.3-fold increase
Structural autoregulation in peripheral vascular beds increases flow resistance in response to elevated pressure, potentially amplifying and stabilizing hypertension.
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Elevated pressure may amplify resistance via autoregulation in rat models; leaves open relevance to human hypertension.
Pries et al. (2001) studied Hypertension (n=6). Increased driving pressure vs. Normal driving pressure was evaluated on Flow resistance (3.3-fold increase). Increasing driving pressure from 15% to 190% of normotensive values in a theoretical model of rat microvascular networks resulted in a 3.3-fold increase in flow resistance.
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