Key result
Peak wall shear in the descending thoracic aorta of a dog approached 270 dyne/cm² under increased flow, close to the critical yield stress of 400 dyne/cm² for endothelial cell erosion.
Population
Excised segments of blood vessels (descending thoracic aorta of a dog)
Design
Preclinical
Authors
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High-flow aortic shear nears endothelial yield in dogs; leaves open shear role in human atherogenesis.
The study demonstrates that peak wall shear stress in the descending thoracic aorta under increased flow approaches the critical yield stress for endothelial cells, providing insights into vessel wall permeability and atherosclerosis pathogenesis.
Vaishnav et al. (1978) studied Atherosclerosis pathogenesis and vessel wall permeability. Mechanical stress and pulsatile blood flow was evaluated on Endothelial erosion and wall shear stress. Peak wall shear in the descending thoracic aorta of a dog approached 270 dyne/cm² under increased flow, close to the critical yield stress of 400 dyne/cm² for endothelial cell erosion.
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