Key result
Echocardiography identified left coronary ostial stenosis in 3 of 3 homozygotes and abnormal aortic cusp echoes in 10 of 32 heterozygotes with familial hypercholesterolemia.
Why the study?
Does cross-sectional echocardiographic assessment detect aortic root abnormalities and coronary ostial stenosis in patients with familial hypercholesterolaemia?
Population
35 patients with familial types IIa and IIb hyperlipoproteinaemia, including 3 homozygotes and 32…
Comparison
Cross-sectional echocardiographic assessment vs Control group
Design
Cross-sectional
Authors
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Echocardiography may detect ostial stenosis and aortic abnormalities in familial hypercholesterolemia; leaves open its clinical utility pending prospective studies.
Cross-Sectional (n=35)
Does cross-sectional echocardiographic assessment detect aortic root abnormalities and coronary ostial stenosis in patients with familial hypercholesterolaemia?
Echocardiography can effectively detect severe aortic root atheroma, supravalvular stenosis, and coronary ostial stenosis in patients with familial hypercholesterolaemia, particularly in homozygotes.
Ribeiro et al. (1983) conducted a cross-sectional in Familial hypercholesterolaemia (n=35). Echocardiography vs. Control group was evaluated on Aortic root abnormalities and coronary ostial stenosis. Echocardiography identified left coronary ostial stenosis in 3 of 3 homozygotes and abnormal aortic cusp echoes in 10 of 32 heterozygotes with familial hypercholesterolemia.
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