Key result
Homozygous familial hypercholesterolemia with supravalvular stenosis is linked to ~36% lower coronary flow velocity reserve.
Why the study?
Coronary artery haemodynamics in adolescents with homozygous familial hypercholesterolaemia and aortic supravalvular stenosis were not well characterized.
Does homozygous familial hypercholesterolaemia with aortic supravalvular stenosis reduce coronary flow velocity reserve compared to heterozygous familial hypercholesterolaemia in adolescents?
Comparison
Homozygous familial hypercholesterolaemia with aortic supravalvular stenosis vs heterozygous familial hypercholesterolaemia
Design
Observational study
Authors
Loading...
May indicate heightened ischemic vulnerability in homozygous FH adolescents with supravalvular stenosis; hypothesis-generating and should not yet alter practice.
Observational (n=18)
Does homozygous familial hypercholesterolaemia with aortic supravalvular stenosis reduce coronary flow velocity reserve compared to heterozygous familial hypercholesterolaemia in adolescents?
Absolute Event Rate: 1.97% vs 3.08%
Adolescents with homozygous familial hypercholesterolaemia and aortic supravalvular stenosis have significantly reduced coronary flow velocity reserve compared to those with heterozygous familial hypercholesterolaemia.
Wang et al. (2012) conducted an observational in Familial hypercholesterolaemia (n=18). Homozygous familial hypercholesterolaemia with aortic supravalvular stenosis vs. Heterozygous familial hypercholesterolaemia was evaluated on Mean coronary flow velocity reserve. Homozygous familial hypercholesterolaemic adolescents with aortic supravalvular stenosis had a lower mean coronary flow velocity reserve compared to heterozygous patients (1.97 vs 3.08).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: