Key result
Asymptomatic patients with homozygous familial hypercholesterolemia had significantly lower hyperemic flow velocities and coronary flow velocity reserve than controls.
Why the study?
Does transthoracic Doppler echocardiography detect early coronary abnormalities in asymptomatic patients with homozygous familial hypercholesterolemia?
Population
17 asymptomatic patients with homozygous familial hypercholesterolemia (HoFH) and 10 controls (total n=27).
Comparison
Transthoracic Doppler echocardiography of the… vs Controls without HoFH.
Design
Case-control
Authors
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Supports noninvasive TTE detection of microvascular dysfunction in asymptomatic homozygous FH; hypothesis-generating and should not yet change practice.
Case-Control (n=27)
Does transthoracic Doppler echocardiography detect early coronary abnormalities in asymptomatic patients with homozygous familial hypercholesterolemia?
Transthoracic Doppler echocardiography can noninvasively detect early coronary microvascular dysfunction (reduced CFVR) in asymptomatic patients with homozygous familial hypercholesterolemia.
Zhang et al. (2010) conducted a case-control in Homozygous familial hypercholesterolemia (n=27). Homozygous familial hypercholesterolemia vs. Controls was evaluated on Coronary flow velocity reserve (CFVR) and hyperemic flow velocities. Asymptomatic patients with homozygous familial hypercholesterolemia had significantly lower hyperemic flow velocities and coronary flow velocity reserve than controls.
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