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Z-disc recognition as signaling node supports targeted cardiomyopathy research; leaves open interventional validation before clinical adoption.
During the last 15 years, the perception of the cardiac z-disc has undergone substantial changes. Initially viewed as a structural component at the lateral boundaries of the sarcomere, the cardiac z-disc has increasingly become recognized as a nodal point in cardiomyocyte signal transduction and disease. This minireview thus focuses on novel components and recent developments in z-disc biology and their role in cardiac signaling and disease.
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Frank et al. (2011) studied this question.
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