Key result
Mechanical stress sensors embedded in the cardiac cytoskeleton, such as Z disks and titin filaments, regulate adaptive remodeling and signal transduction in response to mechanical demands.
Population
Cardiac muscle and cytoskeleton (Z disk, titin, and associated structures)
Design
Review
Authors
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Cytoskeletal mechanosensors regulate cardiac remodeling; leaves open their therapeutic targeting in heart failure.
This review highlights the complex mechanical stress-strain sensory mechanisms embedded in the cardiac cytoskeleton, which are crucial for understanding physiological remodeling and the development of cardiac pathologies.
Masahiko Hoshijima (2006) conducted a review in Cardiac remodeling and pathologies. Mechanical stress sensors embedded in the cardiac cytoskeleton, such as Z disks and titin filaments, regulate adaptive remodeling and signal transduction in response to mechanical demands.
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