Key result
Inverse mathematical modeling compares two numerical techniques for evaluating contractile force in normal heart cells.
Population
Mathematical model of normal heart cells (cardiac myocytes)
Design
Preclinical
Authors
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Computational method for myocyte force remains preclinical; leaves open its utility for human heart failure mechanobiology.
An inverse problem approach using mathematical modeling can evaluate contractile force in cardiac myocytes, providing insights into mechanosensation and potential maladaptation in heart failure.
Arif et al. (2017) studied Mechanosensation in normal heart cells. Mathematical modeling (inverse problem approach) was evaluated on Computational efficiency and accuracy of numerical techniques. An inverse problem approach using a mathematical model evaluated the contractile force in normal heart cells, comparing the computational efficiency and accuracy of two numerical techniques.
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