Key result
Cardiac Z-discs function not only as a physical anchor for myofilament and cytoskeletal proteins, but also as a pivot for reception, transduction, and transmission of signals.
This review highlights the evolving understanding of cardiac Z-discs as dynamic signaling hubs rather than just structural anchors in myocardial physiology and pathology.
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Advances Z-disc signaling insights in cardiomyopathy; extends structural paradigms but leaves open therapeutic targeting.
Pyle et al. (2004) conducted a review in Cardiac Z-disc function and structure. Cardiac Z-discs function not only as a physical anchor for myofilament and cytoskeletal proteins, but also as a pivot for reception, transduction, and transmission of signals.
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