Key result
The sarcomeric Z-disc and its associated proteins play a crucial role in cardiomyocyte signaling, mechanotransduction, and the pathogenesis of dilated and hypertrophic cardiomyopathy.
This review emphasizes the emerging role of the sarcomeric Z-disc in cardiomyocyte signaling and its involvement in the pathogenesis of cardiomyopathies.
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Should not yet change cardiomyopathy management; leaves open Z-disc proteins as targets for mechanistic and therapeutic research.
The Z-disc has traditionally been viewed as a structure required to maintain sarcomeric function and integrity. More recently, the sarcomeric Z-disc has also emerged as a nodal point in cardiomyocyte signaling and mechanotransduction. This notion is not only supported by several transgenic animal models, but also by the identification of mutations in various Z-disc proteins, resulting in dilated or hypertrophic cardiomyopathy in patients. This review will thus focus on the role of the sarcomeric Z-disc and its associated proteins in the pathogenesis of cardiomyopathy.
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Frank et al. (2007) conducted a review in Cardiomyopathy. Sarcomeric Z-disc and associated proteins was evaluated. The sarcomeric Z-disc and its associated proteins play a crucial role in cardiomyocyte signaling, mechanotransduction, and the pathogenesis of dilated and hypertrophic cardiomyopathy.
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