Key result
Hypertensive subjects had a significantly higher QT variability index compared to normotensive controls (P<0.001), which correlated with the severity of left ventricular hypertrophy.
Why the study?
Does arterial hypertension with left ventricular hypertrophy alter temporal cardiac repolarization (QT variability) compared to normotensive controls and HCM patients?
Cross-Sectional (n=83)
Does arterial hypertension with left ventricular hypertrophy alter temporal cardiac repolarization (QT variability) compared to normotensive controls and HCM patients?
p-value: p=<0.001
Hypertension with left ventricular hypertrophy is associated with increased temporal cardiac repolarization abnormalities (QT variability), which may contribute to the risk of malignant ventricular arrhythmias.
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May indicate repolarization instability in hypertensive LVH; hypothesis-generating and requires prospective validation before risk stratification use.
Piccirillo et al. (2002) conducted a cross-sectional in Arterial hypertension with left ventricular hypertrophy (n=83). Arterial hypertension vs. Normotensive controls and HCM patients with ICD was evaluated on QT variability index (QTVI), QT-RR slope, and spectral QT variability (p=<0.001). Hypertensive subjects had a significantly higher QT variability index compared to normotensive controls (P<0.001), which correlated with the severity of left ventricular hypertrophy.
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