Key result
Acute autonomic modulation via atrial pacing significantly increased QT variability in heart failure patients compared to subjects with normal hearts (P=0.008).
Why the study?
Does acute autonomic nervous system modulation affect QT variability in heart failure patients prone to ventricular tachycardia?
Population
29 subjects: 10 heart failure patients with spontaneous ventricular tachycardia [HFVT], 10 HF patients…
Comparison
Acute autonomic interventions including atrial… vs Baseline measurements and comparison between…
Design
Cross-sectional
Authors
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Highlights potential autonomic contribution to repolarization instability in heart failure; leaves open therapeutic implications pending longitudinal data.
Observational (n=29)
Does acute autonomic nervous system modulation affect QT variability in heart failure patients prone to ventricular tachycardia?
Heart failure patients with spontaneous ventricular tachycardia exhibit increased QT variability that is not solely driven by heart rate variation and is relatively resistant to acute autonomic modulation.
Nayyar et al. (2013) conducted an observational in Heart failure prone to ventricular tachycardia (n=29). Atrial pacing, esmolol, isoprenaline, and atropine infusion vs. Baseline and subjects with structurally normal hearts was evaluated on QT variability (SDQT and SDQT-to-SDRR ratio). Acute autonomic modulation via atrial pacing significantly increased QT variability in heart failure patients compared to subjects with normal hearts (P=0.008).
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