What is the clinical evidence from this study?

Study design: Observational. Population: Drug-resistant atrial fibrillation or atrial flutter (n=14). Intervention: Atrioventricular node catheter ablation using radiofrequency current vs. Baseline (preablation). Primary outcome: Left ventricular ejection fraction (EF) (p=< 0.05).

What question did this study set out to answer?

This research aims to evaluate the hemodynamic effects of atrioventricular node ablation using radiofrequency current in patients with atrial fibrillation and impaired ventricular function.

June 1, 1993Pacing and Clinical Electrophysiology

Effects on Cardiac Performance of Atrioventricular Node Catheter Ablation Using Radiofrequency Current for Drug‐Refractory Atrial Arrhythmias

Q: What are the key findings of this study?

Radiofrequency catheter ablation of the AV node in patients with drug-resistant AF significantly improved left ventricular ejection fraction at 6 weeks compared to baseline (47% vs 42%; P<0.05).

Q: What question did this study set out to answer?

This research aims to evaluate the hemodynamic effects of atrioventricular node ablation using radiofrequency current in patients with atrial fibrillation and impaired ventricular function.

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Key result

Radiofrequency catheter ablation of the AV node in patients with drug-resistant AF significantly improved left ventricular ejection fraction at 6 weeks compared to baseline (47% vs 42%; P<0.05).

Why the study?

Does AV node catheter ablation with RF current improve cardiac performance in patients with drug-resistant AF?

Population

14 consecutive patients with drug-resistant atrial fibrillation or atrial flutter, mean age 65 +/- 3 years…

Design

Case_series

Follow-up

6 weeks

Authors

NTNicholas TwidaleUniversity of Oklahoma Health Sciences Center KSKaye E. SuttonFlinders Medical Centre LBLYN BARTLETTFlinders Medical Centre

Discussion

Member takes

Implication

May support LVEF gains from AV node ablation in refractory AF; leaves open confirmation in randomized trials.

Key Points

This research aims to evaluate the hemodynamic effects of atrioventricular node ablation using radiofrequency current in patients with atrial fibrillation and impaired ventricular function.
Fourteen patients with drug-resistant atrial fibrillation underwent AV node catheter ablation with RF current and pacemaker implantation.
Monitoring of left ventricular ejection fraction and exercise time before and after ablation was conducted.
Data were collected immediately before and 3 days and 6 weeks after the procedure.
The mean left ventricular ejection fraction improved from 42% preablation to 47% postablation at 6 weeks (P < 0.05).
Exercise time increased from 4.4 minutes preablation to 5.4 minutes postablation after 6 weeks.
No acute cardiodepressant effect was noted due to the RF current during the procedure.

Study Design

Type

Observational (n=14)

Structured PICO

Does AV node catheter ablation with RF current improve cardiac performance in patients with drug-resistant AF?

Population

14 consecutive patients with drug-resistant atrial fibrillation or atrial flutter (AF), mean age 65 +/- 3 years, mean left ventricular ejection fraction 42 +/- 3%.

Intervention

Atrioventricular (AV) node catheter ablation with radiofrequency (RF) current and permanent pacemaker implantation

Outcome

Left ventricular ejection fraction (EF) and exercise time at 6 weeks post-ablation compared to baselinesurrogate

Main Result

Absolute Event Rate: 47% vs 42%

p-value: p=< 0.05

AV node ablation with permanent pacemaker implantation in patients with drug-refractory AF and reduced ventricular function safely improves left ventricular ejection fraction and exercise capacity.

Cite This Study

Twidale et al. (1993) conducted an observational in Drug-resistant atrial fibrillation or atrial flutter (n=14). Atrioventricular node catheter ablation using radiofrequency current vs. Baseline (preablation) was evaluated on Left ventricular ejection fraction (EF) (p=< 0.05). Radiofrequency catheter ablation of the AV node in patients with drug-resistant AF significantly improved left ventricular ejection fraction at 6 weeks compared to baseline (47% vs 42%; P<0.05).

synapsesocial.com/papers/6a0934cfb7dd28a06e160e86 https://doi.org/10.1111/j.1540-8159.1993.tb01714.x

Topics

Persistent AF management Atrial fibrillation AF ablation outcomes Echocardiography Anticoagulation in AF

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Effects on Cardiac Performance of Atrioventricular Node Catheter Ablation Using Radiofrequency Current for Drug‐Refractory Atrial Arrhythmias

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Effects on Cardiac Performance of Atrioventricular Node Catheter Ablation Using Radiofrequency Current for Drug‐Refractory Atrial Arrhythmias

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

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