What does this research mean for the field?

Dynamic contrast-enhanced MRI (DCE-MRI) parameters, particularly quantitative pharmacokinetic measures like K trans, show strong predictive performance and concordant associations with histopathology-based response to neoadjuvant therapy in soft tissue sarcomas. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This review aims to explore how dynamic contrast-enhanced MRI parameters relate to histopathology-based treatment response in soft tissue sarcomas following neoadjuvant therapy.

May 17, 2026Korean Journal of RadiologyOpen Access

Assessing Treatment Response in Soft Tissue Sarcoma Using Dynamic Contrast-Enhanced MRI: A Systematic Review

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Authors

PMPeyman MirghaderiUniversity of Washington NENasim EshraghiUniversity of Washington HLHyeyun LeePusan National University Yangsan Hospital

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Implication

Systematic review evaluates dynamic contrast-enhanced MRI parameters for assessing treatment response in soft tissue sarcomas, indicating the potential for improved evaluation methods.

Key Points

This review aims to explore how dynamic contrast-enhanced MRI parameters relate to histopathology-based treatment response in soft tissue sarcomas following neoadjuvant therapy.
Conducted a systematic review following PRISMA guidelines.
Included 13 studies with a total of 234 patients.
Evaluated quantitative and semi-quantitative DCE-MRI parameters for correlation with treatment response and histopathology.
Quantitative DCE-MRI parameter K trans showed strong predictive performance for treatment response.
Other parameters such as Kep and Ve also demonstrated significant correlation with histopathologic necrosis.
Qualitative features helped differentiate between responders and non-responders, particularly type II curves associated with positive outcomes.

Cite This Study

Mirghaderi et al. (2026) studied this question.

synapsesocial.com/papers/6a095a877880e6d24efe075e https://doi.org/10.3348/kjr.2025.1769

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Implication

Systematic review evaluates dynamic contrast-enhanced MRI parameters for assessing treatment response in soft tissue sarcomas, indicating the potential for improved evaluation methods.

Assessing Treatment Response in Soft Tissue Sarcoma Using Dynamic Contrast-Enhanced MRI: A Systematic Review

Discussion

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Implication

Key Points

Cite This Study

Assessing Treatment Response in Soft Tissue Sarcoma Using Dynamic Contrast-Enhanced MRI: A Systematic Review

Discussion

Member takes

Implication

Key Points

Cite This Study

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