What question did this study set out to answer?

To evaluate the risk, incidence, and timing of pelvic inflammatory disease (PID) and long-term reproductive sequelae resulting from untreated Chlamydia trachomatis infection in women.

May 14, 2010The Journal of Infectious DiseasesOpen Access

Risk of Sequelae afterChlamydia trachomatisGenital Infection in Women

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Authors

CHCatherine L. HaggertyUniversity of Pittsburgh SGSami L. GottliebWorld Health Organization BTBrandie D. TaylorThe University of Texas Medical Branch at Galveston

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Implication

Systematic review reveals varying pelvic inflammatory disease progression rates and up to 18% infertility risk after infection, highlighting critical evidence gaps.

Key Points

To evaluate the risk, incidence, and timing of pelvic inflammatory disease (PID) and long-term reproductive sequelae resulting from untreated Chlamydia trachomatis infection in women.
Reviewed 24 published reports identified through the Centers for Disease Control and Prevention Chlamydia Immunology and Control Expert Advisory Meeting.
Evaluated studies measuring progression to PID, chronic pelvic pain, ectopic pregnancy, and tubal factor infertility following chlamydial infection.
No prospective studies directly assessed the risk of long-term reproductive sequelae, such as infertility, after untreated C. trachomatis infection.
In high-risk settings, 2% to 5% of untreated women developed PID within the ~2-week window between testing positive and treatment, though progression rates in asymptomatic populations appeared low.
Up to 18% of women developed infertility following symptomatic PID of any cause, with repeated chlamydial infections consistently linked to elevated risks of PID and reproductive complications.

Cite This Study

Haggerty et al. (2010) studied this question.

synapsesocial.com/papers/6a095b4a16dfdfe7ed3405c9 https://doi.org/10.1086/652395

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Implication

Systematic review reveals varying pelvic inflammatory disease progression rates and up to 18% infertility risk after infection, highlighting critical evidence gaps.

Risk of Sequelae afterChlamydia trachomatisGenital Infection in Women

Discussion

Member takes

Implication

Key Points

Cite This Study

Risk of Sequelae afterChlamydia trachomatisGenital Infection in Women

Discussion

Member takes

Implication

Key Points

Cite This Study

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