Key result
Beta-blockers impair exercise performance in asymptomatic hypertension but often increase exercise capacity in patients with CAD and angina due to improved angina control.
Why the study?
How do beta-blocking drugs affect exercise performance in normal subjects and patients with hypertension or coronary artery disease?
How do beta-blocking drugs affect exercise performance in normal subjects and patients with hypertension or coronary artery disease?
Beta-blockers have differential effects on exercise capacity depending on the underlying condition, impairing it in uncomplicated hypertension but potentially improving it initially in symptomatic CAD.
Answers are grounded in this paper and cite their sources.
Supports caution with beta-blockers for exercise in asymptomatic hypertension; leaves open prospective trials confirming differential CAD effects.
In brief: Beta-blocking drugs are now? commonly used in patients with hypertension or coronary artery disease (CAD). This article reviews the effects of beta-blockade and recommends exercise prescriptions for patients taking these drugs. In patients with asymptomatic, uncomplicated hypertension, these medications impair exercise performance to some degree, especially endurance exercise or exercise lasting more than 30 minutes. Beta-blockers also hinder these patients' ability to improve performance with training. In patients with CAD and angina, however, exercise capacity often increases substantially because of improved angina control and the effects of peripheral conditioning. However, once their initial deconditioning has been overcome, their capacity for endurance exercise training may be impaired by the effects of beta-blockade on muscle metabolism. This effect may be lessened by the choice of a more cardioselective beta-blocking drug.
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Allen et al. (1984) conducted a review in Hypertension or coronary artery disease. Beta-blocking drugs was evaluated on Exercise performance and capacity. Beta-blockers impair exercise performance in asymptomatic hypertension but often increase exercise capacity in patients with CAD and angina due to improved angina control.
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