Key result
The combined treatment of quercetin and doxorubicin significantly reduced the average tumor weight of liver cancer xenografts to 20 mg compared to 87 mg with doxorubicin alone.
Why the study?
Does quercetin improve doxorubicin-mediated antitumor effects and prevent hepatotoxicity in liver cancer models?
Population
Liver cancer cells, normal liver cells, immune-deficient nude mice with SMMC7721 xenografts, and C57BL/6 mice
Comparison
Quercetin combined with doxorubicin vs Doxorubicin alone, quercetin alone, and normal…
Design
Preclinical
Follow-up
3 weeks (for xenograft model)
Authors
Loading...
Supports preclinical testing of quercetin-doxorubicin combinations in liver cancer; leaves open clinical translation.
Does quercetin improve doxorubicin-mediated antitumor effects and prevent hepatotoxicity in liver cancer models?
Absolute Event Rate: 20% vs 87%
p-value: p=<0.001
Quercetin potentiates the antitumor efficacy of doxorubicin against liver cancer while protecting against doxorubicin-induced hepatotoxicity in preclinical models.
Wang et al. (2012) studied Liver Cancer. Quercetin and Doxorubicin vs. Doxorubicin alone was evaluated on Average tumor weight (p=<0.001). The combined treatment of quercetin and doxorubicin significantly reduced the average tumor weight of liver cancer xenografts to 20 mg compared to 87 mg with doxorubicin alone.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: