June 5, 2014British Journal of PharmacologyOpen Access

Quercetin attenuates doxorubicin cardiotoxicity by modulating B mi‐1 expression

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Why the study?

Does quercetin prevent doxorubicin-induced cardiotoxicity in H9c2 cardiomyocytes and C57BL/6 mice?

Population

H9c2 cardiomyocytes and C57BL/6 mice

Comparison

Quercetin pre-treatment followed by doxorubicin vs Doxorubicin alone

Design

Preclinical

Authors

QDQinghua DongBeijing University of Agriculture LCLong ChenAnhui University QLQunwei LuHuazhong University of Science and Technology

Discussion

Member takes

Implication

Does not support clinical use; leaves open Bmi-1 upregulation as a cardioprotective target in doxorubicin recipients.

Structured PICO

Does quercetin prevent doxorubicin-induced cardiotoxicity in H9c2 cardiomyocytes and C57BL/6 mice?

Population

H9c2 cardiomyocytes and C57BL/6 mice

Intervention

Quercetin pre-treatment followed by doxorubicin

Comparator

Doxorubicin alone (without quercetin pre-treatment)

Outcome

Cardiotoxicity (apoptosis, mitochondrial function, oxidative stress, cardiac function, serum enzyme activity, ROS generation)surrogate

Quercetin attenuates doxorubicin-induced cardiotoxicity in vitro and in vivo by reducing oxidative stress through the up-regulation of Bmi-1 expression.

Cite This Study

Dong et al. (2014) studied this question.

synapsesocial.com/papers/6a71672ea528af2d65c40f5f https://doi.org/10.1111/bph.12795

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