Key result
Discontinuation of antihypertensive medication led to temporary remission in 8% of patients, with 11 individuals maintaining normotension without medication for at least 4 years.
Why the study?
Can adequate blood pressure control be maintained without medication in hypertensive subjects?
Population
n=1138 hypertensive subjects from the Framingham Heart Study cohort taking antihypertensive medication at…
Comparison
Discontinuation of antihypertensive medication vs Continued use of antihypertensive medication
Design
Cohort
Follow-up
up to 12 years
Authors
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May identify remission-prone patients after withdrawal; leaves open predictors, durability, and need for randomized trials.
Cohort (n=1,138)
Can adequate blood pressure control be maintained without medication in hypertensive subjects?
A small proportion of hypertensive patients may experience a period of remission and maintain blood pressure control without medication for several years, though virtually all eventually relapse.
Andrew L. Dannenberg (1987) conducted a cohort in Hypertension (n=1,138). Discontinuation of antihypertensive medication vs. Continued medication was evaluated on Normotension while not receiving medication. Discontinuation of antihypertensive medication led to temporary remission in 8% of patients, with 11 individuals maintaining normotension without medication for at least 4 years.
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