Renal control of sodium homeostasis and its predictive and reactive circadian rhythms are explored as potential contributors to nondipping blood pressure and cardiovascular disease risk.
Blood pressure follows a daily rhythm, dipping during nocturnal sleep in humans. Attenuation of this dip (nondipping) is associated with increased risk of cardiovascular disease. Renal control of sodium homeostasis is essential for long-term blood pressure control. Sodium reabsorption and excretion have rhythms that rely on predictive/circadian as well as reactive adaptations. We explore how these rhythms might contribute to blood pressure rhythm in health and disease.
Ivy et al. (Wed,) conducted a review in Nondipping Blood Pressure. Renal control of sodium homeostasis and its predictive and reactive circadian rhythms are explored as potential contributors to nondipping blood pressure and cardiovascular disease risk.