Key result
Renal sodium circadian rhythms emerge as potential contributors to nondipping blood pressure and CVD risk.
Why the study?
Nondipping nocturnal blood pressure is associated with increased cardiovascular disease risk, but the contribution of predictive and reactive renal sodium handling rhythms remains to be explored.
Answers are grounded in this paper and cite their sources.
This review highlights the potential role of circadian and reactive renal sodium handling in the pathogenesis of nondipping blood pressure and its associated cardiovascular risk.
Blood pressure follows a daily rhythm, dipping during nocturnal sleep in humans. Attenuation of this dip (nondipping) is associated with increased risk of cardiovascular disease. Renal control of sodium homeostasis is essential for long-term blood pressure control. Sodium reabsorption and excretion have rhythms that rely on predictive/circadian as well as reactive adaptations. We explore how these rhythms might contribute to blood pressure rhythm in health and disease.
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Ivy et al. (2020) conducted a review in Nondipping Blood Pressure. Renal control of sodium homeostasis and its predictive and reactive circadian rhythms are explored as potential contributors to nondipping blood pressure and cardiovascular disease risk.
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