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Leukemic stem cells (LSCs) have been identified in acute myeloid leukemia (AML). Similar to haematopoietic stem cells, these LSCs are able to self-renew, differentiate, and proliferate extensively. Recent studies suggest that LSCs are critical for the initiation and maintenance of leukemia. This review will describe the characteristic features of LSCs in AML and the possible targets expressed on the surface of AML, the intracellular targets and the novel molecular and flow cytometry methodologies being used to particularly ablate the LSC population.
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Adhra Al‐Mawali (2013) studied this question.
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