October 23, 2016Journal of Clinical InvestigationOpen Access

Transcription factor ETV1 is essential for rapid conduction in the heart

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Population

Murine models, embryonic heart cultures, neonatal rat atrial cardiomyocytes, and a human phenome-wide…

Comparison

Etv1 deficiency, NRG1 treatment, and kinase… vs Wild-type mice and vehicle control

Design

Preclinical

Authors

ASAkshay ShekharRegeneron (United States)XLXianming LinNYU Langone Health FLFang-Yu LiuShanghai University of Electric Power

Discussion

Member takes

Implication

May inform conduction mechanisms; hypothesis-generating and should not yet change practice.

Structured PICO

Population

Murine models (Etv1 KO, Etv1nlz/+, Cntn2EGFP/+), embryonic heart cultures, neonatal rat atrial cardiomyocytes, and a human phenome-wide association study (PheWAS) cohort (n=29,525; 26,256 European ancestry, 3,269 African ancestry).

Intervention

Etv1 deficiency (knockout), NRG1 treatment, and kinase inhibitors (e.g., AG825, PD98059)

Comparator

Wild-type mice and vehicle control

Outcome

Cardiac conduction physiology, including ECG parameters (P, PR, QRS intervals), fast conduction gene expression (Nkx2-5, Gja5, Scn5a), and sodium current propertiessurrogate

ETV1 is a critical transcription factor regulated by NRG1-MAPK signaling that establishes and maintains fast conduction physiology in the heart, with its deficiency leading to conduction defects.

Cite This Study

Shekhar et al. (2016) studied this question.

synapsesocial.com/papers/6a09ef2ddd65a80ea2512ad7 https://doi.org/10.1172/jci87968

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Transcription factor ETV1 is essential for rapid conduction in the heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Transcription factor ETV1 is essential for rapid conduction in the heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider