Why the study?
Does constitutive activation of alpha1-adrenergic signaling through RTEF-1 alter cardiac conduction and connexin phosphorylation in mice?
Population
Transgenic mice with cardiac-specific overexpression of the transcription factor RTEF-1 and HeLa cells
Comparison
Cardiac-specific overexpression of RTEF-1 vs Wild-type/control mice (implied)
Design
Preclinical
Authors
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RTEF-1 overexpression impairs conduction in mice; leaves open relevance of alpha1-adrenergic signaling to human arrhythmias.
Does constitutive activation of alpha1-adrenergic signaling through RTEF-1 alter cardiac conduction and connexin phosphorylation in mice?
Constitutive activation of alpha1-adrenergic signaling via RTEF-1 causes cardiac conduction defects by upregulating PP1beta and dephosphorylating connexins, providing a potential mechanism for arrhythmias in heart failure.
Chen et al. (2004) studied this question.
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