TEAD-1 Overexpression in the Mouse Heart Promotes an Age-dependent Heart Dysfunction
Population
Transgenic mice expressing hemagglutinin-tagged TEAD-1 under the control of the muscle creatine kinase…
Design
Preclinical
Authors
Discussion
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Implication
Supports TEAD-1 as mediator of maladaptive remodeling; hypothesis-generating for cardiomyopathy but leaves open human therapeutic relevance.
Structured PICO
P
Population
Transgenic mice expressing hemagglutinin-tagged TEAD-1 under the control of the muscle creatine kinase promoter
I
Intervention
Sustained increase in TEAD-1 protein (overexpression)
O
Outcome
Age-dependent cardiac dysfunction (cardiac output, stroke volume, ejection fraction, and fractional shortening)surrogate
Increased TEAD-1 expression in vivo induces characteristics of cardiac remodeling associated with cardiomyopathy and heart failure, and abolishes tolerance to pressure overload.
Cite This Study
Tsika et al. (2010) studied this question.