Key result
Experimental HeN-2022 infection in sheep drives robust antibodies and asymptomatic shedding peaking at 5 days.
Why the study?
Bovine enteroviruses are emerging pathogens with poorly understood evolutionary dynamics and zoonotic potential.
Population
Cattle in China and experimentally infected sheep
Comparison
Experimental infection with recombinant BEV strain HeN-2022
Design
Genomic, phylogenetic, divergence dating, and experimental infection study
Authors
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May signal silent cross-species transmission risk from recombinant enteroviruses; leaves open zoonotic surveillance needs in livestock.
The discovery of a novel recombinant bovine enterovirus strain capable of cross-species infection in sheep highlights recombination as a driver of viral evolution and zoonotic potential.
Feng et al. (2025) studied Bovine enterovirus infection. Experimental infection with HeN-2022 strain was evaluated on Viral shedding and neutralizing antibody responses. Experimental infection of sheep with the novel recombinant bovine enterovirus strain HeN-2022 demonstrated asymptomatic viral shedding peaking at 5 days post-infection and robust antibody responses.
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