Key result
Higher sFlt-1/PlGF ratio correlates with greater LVMI and E/e' in hypertensive disorders of pregnancy.
Why the study?
Maternal cardiovascular impairment occurs in hypertensive disorders of pregnancy (HDP), but the correlation between cardiac indices by TTE and circulating angiogenic markers remained to be evaluated.
Do circulating angiogenic markers correlate with maternal echocardiographic indices in women with hypertensive disorders of pregnancy?
Population
95 women with HDP and 25 controls with uncomplicated pregnancy at term
Comparison
Women with HDP vs uncomplicated pregnancy controls
Design
Prospective observational study
Authors
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Hypothesis-generating for cardiac assessment in HDP; prospective studies needed before clinical adoption.
Observational (n=120)
Do circulating angiogenic markers correlate with maternal echocardiographic indices in women with hypertensive disorders of pregnancy?
Circulating angiogenic markers (sFlt-1 and PlGF) correlate with maternal echocardiographic indices of left ventricular remodeling and diastolic dysfunction in women with hypertensive disorders of pregnancy.
Giorgione et al. (2023) conducted an observational in Hypertensive disorders of pregnancy (n=120). Circulating angiogenic markers (sFlt-1, PlGF) and transthoracic echocardiography vs. Uncomplicated pregnancy at term was evaluated on Correlation between cardiac indices obtained by transthoracic echocardiography and circulating angiogenic markers. In women with hypertensive disorders of pregnancy, the sFlt-1/PlGF ratio significantly correlated with left ventricular mass index (r=0.252; P=0.022) and E/e' ratio (r=0.269; P=0.014).