Why the study?
Pregnancy in women with CHD carries increased risks of obstetric and neonatal complications, and placental dysfunction has been hypothesized to contribute but underlying mechanisms remain unclear.
Do pregnant women with congenital heart disease exhibit placental angiogenic imbalance, and is it associated with adverse pregnancy outcomes?
Population
95 pregnant women (32 with CHD and 63 healthy controls)
Comparison
Pregnant women with CHD vs healthy controls
Design
Prospective study
Authors
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Angiogenic imbalance may flag higher risk in pregnant CHD patients; hypothesis-generating and requires prospective validation before clinical use.
Do pregnant women with congenital heart disease exhibit placental angiogenic imbalance, and is it associated with adverse pregnancy outcomes?
Pregnant women with congenital heart disease exhibit a placental angiogenic imbalance in late pregnancy, which is associated with a significantly higher risk of adverse obstetric and neonatal outcomes.
Rahnama et al. (2025) studied this question.
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