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August 16, 2026NutrientsOpen Access

Association Between Maternal Angiogenic Markers in Hypertensive Disorders of Pregnancy and Neonatal Growth and Body Composition

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Authors

NSNawa SchirwaniJBJulia BinderPPPilar Palmrich

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Overview

Cohort study reveals higher maternal sFlt-1/PlGF ratios associate with reduced fat-free mass in preterm infants, indicating vascular biomarkers may influence neonatal growth.

Key Points

  • To determine whether maternal angiogenic markers in hypertensive disorders of pregnancy are associated with postnatal neonatal growth and body composition.
  • Secondary analysis of a prospective cohort study conducted at the Medical University of Vienna evaluating 94 infants born to mothers with hypertensive disorders of pregnancy, stratified into preterm (<37 weeks, n = 72) and term (≥37 weeks, n = 22) groups.
  • Maternal soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) were measured when hypertensive disorders of pregnancy were first suspected, and infant body composition was assessed at term-equivalent age.
  • In preterm infants, higher sFlt-1/PlGF ratios significantly correlated with lower fat-free mass (FFM) z-scores (rs = −0.408; p = 0.004), but not with fat mass (p = 0.21), weight (p = 0.19), length (p = 0.31), or head circumference z-scores (p = 0.32).
  • Multivariable linear regression adjusted for neonatal confounders confirmed higher sFlt-1/PlGF ratios were independently associated with reduced FFM in preterm infants (median: −0.10, 95% CI: −0.20 to 0.00; p = 0.036).
  • In term infants, sFlt-1/PlGF ratios showed no significant correlations with FFM (p = 0.86), fat mass (p = 0.41), weight (p = 0.10), length (p = 0.12), or head circumference (p = 0.20).

Cite This Study

Schirwani et al. (2026) studied this question.

synapsesocial.com/papers/6a8179eff2fb91fc834ad5eehttps://doi.org/10.3390/nu18162653
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiogenic Biomarkers and Neonatal Outcomes in Suspected Preeclampsia: Retrospective Cohort Study2025 · 4 citations
  2. 2Beyond Diagnostic Cut-Offs: Associations Between the sFlt-1/PlGF Ratio and Perinatal Outcomes in Low-Risk Term Pregnancies2026
  3. 3Placental Angiogenic Imbalance and Its Association With Adverse Outcomes in Congenital Heart Disease Pregnancies2025
  4. 4Angiogenic markers as promising prognostic indicators for maternal blood pressure changes and pregnancy complications2026
  5. 5sFlt-1/PlGF Ratio as a Central Biomarker for Preeclampsia and Perinatal Outcomes: A Multisystem Retrospective Cohort Study2026 · 3 citations