Key result
Preeclampsia is associated with impaired diastolic left ventricular function (higher septal E/E' ratio, P<0.0001) and increased NT-pro-BNP and cystatin C levels compared to normal pregnancy.
Why the study?
Does preeclampsia impair left ventricular function and alter cardiovascular biomarkers compared to normal pregnancy?
Case-Control (n=65)
Does preeclampsia impair left ventricular function and alter cardiovascular biomarkers compared to normal pregnancy?
Preeclampsia, particularly early-onset, is associated with impaired diastolic left ventricular function and elevated cardiovascular biomarkers compared to normal pregnancy.
Answers are grounded in this paper and cite their sources.
May warrant postpartum cardiac monitoring in preeclampsia; leaves open whether findings predict long-term events.
AIM: To assess left ventricular (LV) structure and function in preeclampsia, a serious vascular-related pregnancy disorder, by Doppler tissue imaging (DTI) in combination with the levels of cardiovascular biomarkers. MATERIAL AND METHODS: Thirty-five pregnant women with preeclampsia and 30 with normal pregnancy, matched for age and gestational age were examined during pregnancy and 3-6 months after delivery. Transthoracic echocardiography and DTI were performed and blood levels of amino-terminal pro-brain natriuretic peptide (NT-pro-BNP), C-reactive protein (CRP), cystatin C and troponin I were analyzed. RESULTS: There were significant differences in LV and left atrial dimensions and function between the groups. A higher septal and lateral E/E' ratio (E = early transmitral diastolic flow velocity and E' = early diastolic myocardial velocity) (P < 0.0001, 0.0008) and higher levels of NT-pro-BNP, cystatin C, and lower cystatin C estimated GFR in ml/min per 1.73 m(2) (P < 0.0001) were seen in the preeclampsia both during pregnancy and at follow-up. In addition the levels of E/E' ratio lateral and NT-pro-BNP were higher in pregnant women with early-onset preeclampsia necessitating delivery before 34 weeks of gestation than those who developed preeclampsia and delivered at or after 34 weeks (P = 0.0004, 0.005). CONCLUSION: In pregnancies complicated by preeclampsia, especially early-onset preeclampsia, the diastolic LV function is impaired and levels of biomarkers, NT-pro-BNP and cystatin C, are increased in comparison to normal pregnancy.
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Hamad et al. (2009) conducted a case-control in Preeclampsia (n=65). Preeclampsia vs. Normal pregnancy was evaluated on Left ventricular structure and function (E/E' ratio) and cardiovascular biomarkers (p=<0.0001). Preeclampsia is associated with impaired diastolic left ventricular function (higher septal E/E' ratio, P<0.0001) and increased NT-pro-BNP and cystatin C levels compared to normal pregnancy.
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