Key result
Lack of effective HFpEF therapies highlights the need for representative rodent models.
Why the study?
Despite severe mortality and symptoms comparable to HFrEF, no known therapeutic agents improve survival in HFpEF.
Design
Review
Authors
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HFpEF treatment gap persists; leaves open which rodent models best accelerate therapy development.
This review highlights the clinical features of HFpEF and the importance of animal models in understanding its molecular mechanisms, emphasizing the unmet need for effective therapies.
Yoon et al. (2019) conducted a review in Heart failure with preserved ejection fraction (HFpEF). Heart failure with preserved ejection fraction currently lacks effective pharmacological treatments, highlighting the need for continued research using representative rodent models.
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