Why the study?
Respiratory neural centers in the brainstem are difficult to localize on MRI and study with fMRI due to small size, lack of visually detectable borders, and physiological noise.
This review summarizes the methodological challenges and current approaches for using fMRI to evaluate central respiratory control in the human brainstem and suprapontine structures.
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Alerts researchers to fMRI pitfalls in respiratory control; leaves open standardized protocols for clinical translation.
Ciumas et al. (2022) studied this question.
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