May 1, 1994Journal of Applied Physiology
Localization of putative neural respiratory regions in the human by functional magnetic resonance imaging
Why the study?
Does hypercapnic ventilatory challenge activate specific neural respiratory regions in healthy volunteers as measured by fMRI?
Population
11 healthy volunteers
Comparison
Breathing 5% CO2-95% O2 vs Breathing 100% O2
Design
Other
Authors
Discussion
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Member takes
Implication
fMRI enables noninvasive mapping of human brainstem respiratory centers; leaves open translation to patients with ventilatory disorders.
Structured PICO
Does hypercapnic ventilatory challenge activate specific neural respiratory regions in healthy volunteers as measured by fMRI?
P
Population
11 healthy volunteers
I
Intervention
Breathing 5% CO2-95% O2 (and 10% CO2-90% O2 in one subject)
C
Comparator
Breathing 100% O2
O
Outcome
Changes in brain tissue microcirculation (image signal intensity) assessed by fMRIsurrogate
fMRI can identify patterns of activation in brain stem and cerebellar regions during hypercapnic ventilatory challenge in humans.
Cite This Study
Gozal et al. (1994) studied this question.