Functional MRI localisation of central nervous system regions associated with volitional inspiration in humans
Key result
Volitional inspiration significantly increased fMRI BOLD signals in the superior motor, premotor, and supplementary motor cortices compared to mechanical ventilation.
Why the study?
Does voluntary breathing compared to mechanical ventilation activate specific central nervous system regions detectable by fMRI in healthy men?
Population
5 healthy men
Comparison
Voluntary breathing (active task) during fMRI vs Mechanical ventilation (passive task) during fMRI
Design
Other
Authors
Discussion
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Member takes
Implication
fMRI maps volitional respiratory motor activation; extends neuroimaging methods but leaves open clinical translation.
Structured PICO
Does voluntary breathing compared to mechanical ventilation activate specific central nervous system regions detectable by fMRI in healthy men?
P
Population
5 healthy men
I
Intervention
Voluntary breathing (active task) during fMRI
C
Comparator
Mechanical ventilation (passive task) during fMRI
O
Outcome
Whole brain blood oxygenation level-dependent (BOLD) changes identifying areas of neuronal activationsurrogate
This study demonstrates that fMRI can successfully identify and localize respiratory-related neuronal activity during volitional inspiration with high spatial and temporal resolution.
Cite This Study
Evans et al. (1999) studied Healthy volunteers (n=5). Voluntary breathing (volitional inspiration) vs. Mechanical ventilation (passive task) was evaluated on Neuronal activation (BOLD changes) associated with volitional inspiration. Volitional inspiration significantly increased fMRI BOLD signals in the superior motor, premotor, and supplementary motor cortices compared to mechanical ventilation.