Key result
Angiotensin II infusion in rats decreased kidney MnSOD activity (11 vs 24 U/mg) and increased total 3-nitrotyrosine content (9.5 vs 3.2 ng/mg protein) compared to sham treatment.
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Highlights potential oxidative mechanisms in Ang II kidney effects; leaves open translation to human hypertension.
Absolute Event Rate: 11% vs 24%
Guo et al. (2003) studied Angiotensin II-induced hypertension. Angiotensin II infusion vs. Sham treated was evaluated on MnSOD activity (U/mg). Angiotensin II infusion in rats decreased kidney MnSOD activity (11 vs 24 U/mg) and increased total 3-nitrotyrosine content (9.5 vs 3.2 ng/mg protein) compared to sham treatment.
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