Key result
Antioxidant therapy and captopril reduce cerebral oxidative stress and nitrotyrosine abundance in rats with CRF.
Why the study?
Reactive oxygen species activity and neuronal NO synthase expression are increased in the brain in chronic renal failure, suggesting increased tyrosine nitration in the uremic brain.
Does antioxidant therapy or captopril reduce cerebral tyrosine nitration in rats with chronic renal failure?
Population
Rats with chronic renal failure 6 weeks after 5/6 nephrectomy
Comparison
Antioxidant (lazaroid) or captopril treatment vs sham-operated controls and untreated CRF rats
Design
Preclinical experimental study
Follow-up
6 weeks
Authors
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Hypothesis-generating for neuroprotection in uremia; does not support clinical use in chronic kidney disease.
Does antioxidant therapy or captopril reduce cerebral tyrosine nitration in rats with chronic renal failure?
Antioxidant therapy and ACE inhibition alleviate CRF-induced oxidative stress and mitigate tyrosine nitration in the cerebral cortex of rats.
Deng et al. (2001) studied Chronic renal failure. Antioxidant (lazaroid) or captopril vs. Untreated rats with chronic renal failure and sham-operated controls was evaluated on Nitrotyrosine abundance and distribution in the cerebrum. Antioxidant therapy and captopril administration alleviated oxidative stress and significantly reduced nitrotyrosine abundance in the cerebral cortex of rats with chronic renal failure.
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