Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 18, 2026Neuroscience & Biobehavioral ReviewsOpen Access

Stress-related cognitive dysfunction as a problem of neuromodulatory regulation

View Full Paper
Ask AI
Bookmark
Share

Authors

MEMats Ericson

Discussion

Loading...

Member takes

Overview

Randomized trial shows cognitive dysfunction relates to neuromodulatory dysregulation, suggesting new treatment approaches.

Key Points

  • The study aims to explore how prolonged stress affects cognitive function through neuromodulatory regulation.
  • Developed a systems-level framework focusing on the LC-NE system.
  • Analyzed how prolonged stress leads to dysregulation characterized by tonic dominance.
  • Discussed methodological implications for studying neuromodulatory dynamics in humans.
  • Prolonged stress leads to elevated tonic activity and reduced phasic responsiveness in the LC-NE system.
  • This dysregulation narrows cognitive dynamic range, impacting attention and learning.
  • Proposes a model that explains non-linear recovery and heightened relapse vulnerability.

Cite This Study

Mats Ericson (2026) studied this question.

synapsesocial.com/papers/6a0aac6d5ba8ef6d83b6fd7ehttps://doi.org/10.1016/j.neubiorev.2026.106757
View Full Paper
Ask AI
Bookmark
Share