What question did this study set out to answer?

To assess body composition and nutritional status in patients undergoing resection for Crohn's disease and determine their impact on postoperative clinical outcomes.

October 20, 2023Inflammatory Bowel DiseasesOpen Access

Obesity, Sarcopenia and Myosteatosis: Impact on Clinical Outcomes in the Operative Management of Crohn’s Disease

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Authors

MDMark Donnelly DDDorothee Driever ÉRÉanna J. Ryan

Discussion

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Overview

Cohort study demonstrates that myosteatosis independently increases postoperative morbidity after Crohn's disease resection, highlighting muscle quality as a critical target for surgical optimization.

Key Points

To assess body composition and nutritional status in patients undergoing resection for Crohn's disease and determine their impact on postoperative clinical outcomes.
Evaluated 124 consecutive patients with Crohn's disease undergoing surgical resection between 2000 and 2018.
Quantified preoperative body composition—including visceral fat, subcutaneous fat, lean tissue area, and intramuscular adipose tissue (IMAT)—using L3 computed tomography scans.
Analyzed predictors of postoperative morbidity using univariable and multivariable linear, logistic, and Cox proportional hazards regression models.
IMAT independently predicted increased overall postoperative morbidity (OR, 1.08; 95% CI, 1.01–1.16; P = .037) and a higher comprehensive complications index (P = .029).
Visceral fat area independently predicted venous thromboembolism (OR, 1.02; 95% CI, 1.00–1.05; P = .028), while total fat area was associated with wound infection (OR, 1.00; 95% CI, 1.00–1.01; P = .042).

Cite This Study

Donnelly et al. (2023) studied this question.

synapsesocial.com/papers/6a0aaf129b4eb2f7ce2e0271 https://doi.org/10.1093/ibd/izad225

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October 20, 2023Inflammatory Bowel DiseasesOpen Access

Obesity, Sarcopenia and Myosteatosis: Impact on Clinical Outcomes in the Operative Management of Crohn’s Disease

View Full Paper

Ask AI

Bookmark

Authors

MDMark Donnelly DDDorothee Driever ÉRÉanna J. Ryan

Discussion

Member takes

Overview

Key Points

To assess body composition and nutritional status in patients undergoing resection for Crohn's disease and determine their impact on postoperative clinical outcomes.
Evaluated 124 consecutive patients with Crohn's disease undergoing surgical resection between 2000 and 2018.
Quantified preoperative body composition—including visceral fat, subcutaneous fat, lean tissue area, and intramuscular adipose tissue (IMAT)—using L3 computed tomography scans.
Analyzed predictors of postoperative morbidity using univariable and multivariable linear, logistic, and Cox proportional hazards regression models.
IMAT independently predicted increased overall postoperative morbidity (OR, 1.08; 95% CI, 1.01–1.16; P = .037) and a higher comprehensive complications index (P = .029).
Visceral fat area independently predicted venous thromboembolism (OR, 1.02; 95% CI, 1.00–1.05; P = .028), while total fat area was associated with wound infection (OR, 1.00; 95% CI, 1.00–1.01; P = .042).

Cite This Study

Donnelly et al. (2023) studied this question.

synapsesocial.com/papers/6a0aaf129b4eb2f7ce2e0271 https://doi.org/10.1093/ibd/izad225

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