Key result
RVP-induced dyssynchrony reduces myocyte function and increases gene expression heterogeneity ~10-fold versus resynchronization.
Why the study?
Long-term cardiac pacing has eluded translation in mice, despite their widespread use in experimental biology.
A novel method for chronic pacing in conscious mice demonstrates that right ventricular pacing-induced dyssynchrony impairs heart function and alters gene expression, which can be reversed by resynchronization.
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Offers a conscious murine model for dyssynchrony research; leaves open clinical translation to human resynchronization.
Ståhlberg et al. (2019) studied Cardiac ischemia/reperfusion injury and pacing-induced dyssynchrony. Chronic right ventricular pacing (dyssynchrony) vs. Right atrial pacing (synchrony) or resynchronization was evaluated on Heart and myocyte function, gene expression heterogeneity, and kinase activity. Right ventricular pacing-induced dyssynchrony substantially reduced heart and myocyte function and increased gene expression heterogeneity (>10 fold) compared with synchrony or resynchronization.
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