What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: End-stage renal disease (ESRD) receiving hemodialysis (n=205). Intervention: Coronary artery and aortic calcification vs. Lower levels of calcification. Primary outcome: Prevalence of myocardial infarction and angina (p=<0.0001).

What question did this study set out to answer?

To identify clinical and laboratory correlates of coronary artery, aortic, and cardiac valve calcification in adult patients with end-stage renal disease receiving maintenance hemodialysis.

May 18, 2026Journal of the American College of Cardiology

Cardiac calcification in adult hemodialysis patients

Q: What are the key findings of this study?

Coronary artery calcium scores were severe (median 595) and directly related to the prevalence of myocardial infarction (p<0.0001) and angina (p<0.0001) in adult hemodialysis patients.

Q: What question did this study set out to answer?

To identify clinical and laboratory correlates of coronary artery, aortic, and cardiac valve calcification in adult patients with end-stage renal disease receiving maintenance hemodialysis.

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Key result

Severe coronary artery calcification is linked to higher MI and angina prevalence in hemodialysis patients.

P<0.0001
n=205

Why the study?

What are the clinical and laboratory correlates of vascular and valvular calcification measured by EBT in adult hemodialysis patients?

Key Points

To identify clinical and laboratory correlates of coronary artery, aortic, and cardiac valve calcification in adult patients with end-stage renal disease receiving maintenance hemodialysis.
Cross-sectional study of 205 adult maintenance hemodialysis patients.
Electron-beam tomography (EBT) was used to measure coronary, aortic, and valvular calcification.
Multivariable linear regression and proportional odds logistic regression analyses were conducted to determine clinical and biochemical correlates.
Coronary artery calcium scores were severe (median 595, interquartile range 76 to 1,600) and significantly associated with myocardial infarction (p < 0.0001) and angina (p < 0.0001).
Aortic calcium scores were directly associated with claudication (p = 0.001) and aortic aneurysm (p = 0.02).
Coronary calcification correlated with older age, male sex, white race, diabetes, longer dialysis vintage, and elevated serum calcium and phosphorus, whereas standard lipid levels showed no significant link.

Study Design

Type

Cross-Sectional (n=205)

Structured PICO

What are the clinical and laboratory correlates of vascular and valvular calcification measured by EBT in adult hemodialysis patients?

Population

205 adult maintenance hemodialysis patients evaluated for vascular and valvular calcification using electron-beam tomography.

Exposure

Electron-beam tomography (EBT) assessment of vascular and valvular calcification

Outcome

Extent of calcification of the coronary arteries, aorta, and mitral and aortic valves and its clinical and laboratory correlatessurrogate

Main Result

p-value: p=<0.0001

Discussion

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Implication

Coronary artery calcification is common and severe in adult ESRD patients on hemodialysis, and is significantly associated with ischemic cardiovascular disease.

Cite This Study

Raggi et al. (2002) conducted a cross-sectional in End-stage renal disease (ESRD) receiving hemodialysis (n=205). Coronary artery and aortic calcification vs. Lower levels of calcification was evaluated on Prevalence of myocardial infarction and angina (p=<0.0001). Coronary artery calcium scores were severe (median 595) and directly related to the prevalence of myocardial infarction (p<0.0001) and angina (p<0.0001) in adult hemodialysis patients.

synapsesocial.com/papers/6a0ad9879b8a9ee5c641a696 https://doi.org/10.1016/s0735-1097(01)01781-8

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Implication

Coronary artery calcification is common and severe in adult ESRD patients on hemodialysis, and is significantly associated with ischemic cardiovascular disease.

Cardiac calcification in adult hemodialysis patients

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Cardiac calcification in adult hemodialysis patients

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider