Key result
Bioelectrical impedance analysis using the Cordain equation strongly correlated with DEXA (r=0.92) and showed 85.7% sensitivity and 100% specificity for predicting excess adiposity.
Why the study?
Does bioelectrical impedance analysis accurately measure fat mass index compared to dual-energy x-ray absorptiometry in patients with spinal muscular atrophy?
Observational (n=16)
Does bioelectrical impedance analysis accurately measure fat mass index compared to dual-energy x-ray absorptiometry in patients with spinal muscular atrophy?
Effect estimate: r=0.92
Bioelectrical impedance analysis is a well-tolerated, noninvasive screening tool for excess adiposity in spinal muscular atrophy, though insufficiently accurate for research purposes.
May support BIA screening for excess adiposity in SMA; leaves open its precision for research fat mass assessment.
Accurate, noninvasive measures of body composition are needed for management of patients with spinal muscular atrophy. Fat mass index (fat mass/height 2 in kg/m 2 ) was measured in 16 subjects with spinal muscular atrophy using 5 bioelectrical impedance analysis equations and compared with a reference method, dual-energy x-ray absorptiometry. The machine default equation, validated by Cordain, was the primary analysis. Fat mass index calculated by impedance measures differed by between -2.5 kg/m 2 and 1.7 kg/m 2 from the reference mean (8.3 ± 5.0 kg/m 2 ). The Cordain equation provided the smallest difference (-0.4 ± 2.0 kg/m 2 ), with correlation coefficient of 0.92. The Cordain equation showed high sensitivity (85.7%) and specificity (100%) for prediction of ‘‘at risk for overweight’’ (fat mass index > 85th percentile for age and gender). Although insufficiently accurate for use as a research tool, bioelectrical impedance can have application as a well-tolerated, noninvasive, easily used screening tool for excess adiposity in patients with spinal muscular atrophy.
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Sproule et al. (2010) conducted an observational in spinal muscular atrophy (n=16). Bioelectrical impedance analysis vs. Dual-energy x-ray absorptiometry was evaluated on Difference in fat mass index compared to reference method (r=0.92). Bioelectrical impedance analysis using the Cordain equation strongly correlated with DEXA (r=0.92) and showed 85.7% sensitivity and 100% specificity for predicting excess adiposity.
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